HISTORY OF CANCER
Today, the Greek term
carcinoma is the medical term for a malignant tumor derived from
epithelial cells. It is
Celsus who translated carcinos into the
Latin cancer, also meaning crab.
Galen used "oncos" to describe all tumours, the root for the modern word
oncology.
Hippocrates described several kinds of cancers. He called benign tumours oncos,
Greek for swelling, and malignant tumours carcinos, Greek for
crab or
crayfish. This name probably comes from the appearance of the cut surface of a solid malignant tumour, with a roundish hard center surrounded by pointy projections, vaguely resembling the shape of a crab (see photo). He later added the suffix -oma, Greek for swelling, giving the name carcinoma. Since it was against Greek tradition to open the body, Hippocrates only described and made drawings of outwardly visible tumors on the skin, nose, and breasts. Treatment was based on the
humor theory of four bodily fluids (black and yellow bile, blood, and phlegm). According to the patient's humor, treatment consisted of diet, blood-letting, and/or laxatives. Through the centuries it was discovered that cancer could occur anywhere in the body, but humor-theory based treatment remained popular until the 19th century with the discovery of
cells.
Though treatment remained the same, in the 16th and 17th centuries it became more acceptable for doctors to
dissect bodies to discover the cause of death. The German professor
Wilhelm Fabry believed that breast cancer was caused by a milk clot in a mammary duct. The Dutch professor
Francois de la Boe Sylvius, a follower of
Descartes, believed that all disease was the outcome of chemical processes, and that acidic lymph fluid was the cause of cancer. His contemporary
Nicolaes Tulp believed that cancer was a poison that slowly spreads, and concluded that it was contagious.
With the widespread use of the microscope in the 18th century, it was discovered that the 'cancer poison' spread from the primary tumor through the lymph nodes to other sites ("
metastasis"). The use of
surgery to treat cancer had poor results due to problems with hygiene. The renowned Scottish surgeon
Alexander Monro saw only 2 breast tumor patients out of 60 surviving surgery for two years. In the 19th century,
asepsis improved surgical hygiene and as the survival statistics went up, surgical removal of the tumor became the primary treatment for cancer. With the exception of
William Coley who in the late 1800s felt that the rate of cure after surgery had been higher before asepsis (and who injected bacteria into tumors with mixed results), cancer treatment became dependent on the individual art of the surgeon at removing a tumor. During the same period, the idea that the body was made up of various tissues, that in turn were made up of millions of cells, laid rest the humor-theories about chemical imbalances in the body. The age of
cellular pathology was born.
With the widespread use of the microscope in the 18th century, it was discovered that the 'cancer poison' spread from the primary tumor through the lymph nodes to other sites ("
metastasis"). The use of
surgery to treat cancer had poor results due to problems with hygiene. The renowned Scottish surgeon
Alexander Monro saw only 2 breast tumor patients out of 60 surviving surgery for two years. In the 19th century,
asepsis improved surgical hygiene and as the survival statistics went up, surgical removal of the tumor became the primary treatment for cancer. With the exception of
William Coley who in the late 1800s felt that the rate of cure after surgery had been higher before asepsis (and who injected bacteria into tumors with mixed results), cancer treatment became dependent on the individual art of the surgeon at removing a tumor. During the same period, the idea that the body was made up of various tissues, that in turn were made up of millions of cells, laid rest the humor-theories about chemical imbalances in the body. The age of
cellular pathology was born.
Cancer patient treatment and studies were restricted to individual physicians' practices until
World War II, when medical research centers discovered that there were large international differences in disease
incidence. This insight drove national public health bodies to make it possible to compile health data across practises and hospitals, a process that many countries do today. The Japanese medical community observed that the bone marrow of bomb victims in
Hiroshima and
Nagasaki was completely destroyed. They concluded that diseased bone marrow could also be destroyed with radiation, and this led to the discovery of bone marrow transplants for
leukemia. Since WWII, trends in
cancer treatment are to improve on a micro-level the existing treatment methods, standardize them, and globalize them as a way to find cures through
epidemiology and international partnerships.